[Atherosclerotic heart defects]

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Updated: Nov 8, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

R B Minkin, S R Minkin

    Kardiologiia
    |January 1, 1993
    PubMed

    Insights

    Cardiac atherosclerosis, often involving valve calcification, rarely occurs alone. Echocardiography and Doppler are superior to phonocardiography for detecting aortic insufficiency and mitral disease.

    Area of Science:

    • Cardiology
    • Medical Imaging

    Background:

    • Cardiac atherosclerosis, particularly valvular calcification, is a significant clinical concern.
    • Understanding the diagnostic capabilities of various imaging modalities is crucial for patient management.

    Purpose of the Study:

    • To compare the diagnostic accuracy of echocardiography, Doppler echocardiography, and phonocardiography in patients with cardiac atherosclerotic lesions.
    • To evaluate the prevalence and patterns of valvular calcification in cardiac atherosclerosis.

    Main Methods:

    • The study involved 31 patients with cardiac atherosclerotic lesions and 20 controls.
    • Clinical, echocardiographic, Doppler echocardiographic, electro-, and phonocardiographic assessments were conducted.

    Main Results:

    • Valvular calcification was rarely isolated, frequently presenting as combined or concurrent defects.
    • Aortic atherosclerotic stenosis detection rates were similar for echocardiography and phonocardiography.
    • Echocardiography and Doppler echocardiography demonstrated superior detection rates (7- and 9-fold) for aortic valvular insufficiency and mitral diseases compared to phonocardiography.

    Conclusions:

    • Cardiac atherosclerotic defects, primarily calcification, are often multifocal.
    • Echocardiography and Doppler echocardiography are more effective than phonocardiography for diagnosing specific valvular conditions like aortic insufficiency and mitral diseases.

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