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Related Experiment Videos

Increase in housing temperature can alleviate decrease in white blood cell counts after energy restriction in C57BL/6

A Koizumi1, N S Roy, M Tsukada

  • 1Department of Hygiene, Akita University School of Medicine, Japan.

Mechanisms of Ageing and Development
|October 1, 1993
PubMed
Summary
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Energy restriction (ER) lowers white blood cell (WBC) counts. However, housing mice at a high temperature partially reversed this effect, indicating temperature can mitigate ER

Area of Science:

  • Physiology
  • Immunology
  • Aging Research

Background:

  • Energy restriction (ER) is known to decrease white blood cell (WBC) counts and inhibit cellular proliferation in rodents.
  • Elevated housing temperatures have previously been shown to counteract the inhibitory effects of ER on cellular proliferation in various organs.

Purpose of the Study:

  • To investigate if a high housing temperature can mitigate the decrease in WBC counts observed after ER.
  • To determine if peripheral WBC counts reflect bone marrow cellular proliferation rates under ER and varying temperatures.

Main Methods:

  • C57BL/6 female mice were divided into control, ER, and ER housed in an incubator (ERI) groups.
  • The ERI group was housed at 30°C, while control and ER groups were housed at 21-23°C.
  • WBC counts were measured at 4 and 13 months of age.

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Main Results:

  • Both ER and ERI groups showed significantly lower WBC counts than controls at both time points.
  • At 13 months, ERI mice exhibited significantly higher WBC counts (194%) compared to ER mice.
  • High housing temperature antagonized the suppressive effect of ER on WBC counts.

Conclusions:

  • A high housing temperature can partially alleviate the reduction in WBC counts caused by energy restriction.
  • These findings suggest that ambient temperature plays a role in modulating the immunological effects of dietary interventions.