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[Candida parapsilosis in reproductive organ infections]
Abstract:
Frequency of occurrence of strains of C. parapsilosis, their susceptibility to drugs and importance in pathogenesis of vaginal mycosis, was evaluated. Strains of C. parapsilosis were isolated in 44 cases which comprises 1.34% of a total number of 3275 tested Candida-like strains. Vaginal mycoses occurred in presence of Lactobacillus sp., normal pH values of vaginal contents, whereas leukocytosis was differing. Following drugs were used for testing susceptibility of C. parapsilosis: nystatin, pimaricin, amphotericin B, flucytosine, cotrimoxazole, miconazole, ketoconazole, tioconazole, fluconazole and itraconazole. It has been demonstrated that 38.3% strains of C. parapsilosis were exhibiting lowered activity toward amphotericin B, nystatin (23.5% resistant) and flucytosine (11.7% resistant). Tested strains were susceptible to remaining drugs within 94.1% and 100%.
Insights
Candida parapsilosis vaginal infections were studied in 44 cases. Most strains remained susceptible to common antifungal drugs, though some resistance to amphotericin B and nystatin was observed.
Area of Science:
- Medical Mycology
- Clinical Microbiology
- Infectious Diseases
Background:
- Candida parapsilosis is an opportunistic fungal pathogen.
- Vaginal mycosis is a common clinical condition.
- Understanding antifungal susceptibility is crucial for effective treatment.
Purpose of the Study:
- To determine the frequency of Candida parapsilosis in vaginal mycosis.
- To evaluate the antifungal drug susceptibility of isolated C. parapsilosis strains.
- To assess the role of C. parapsilosis in the pathogenesis of vaginal mycosis.
Main Methods:
- Isolation and identification of Candida-like strains from vaginal samples.
- Antifungal susceptibility testing of C. parapsilosis isolates against ten drugs.
- Clinical data analysis including presence of Lactobacillus sp., vaginal pH, and leukocytosis.
Main Results:
- Candida parapsilosis accounted for 1.34% of 3275 tested Candida-like strains (44 cases).
- Reduced susceptibility was observed in 38.3% of strains to amphotericin B, 23.5% to nystatin, and 11.7% to flucytosine.
- The remaining tested antifungal drugs showed high susceptibility rates (94.1%-100%).
Conclusions:
- Candida parapsilosis is an infrequent cause of vaginal mycosis.
- While generally susceptible, emerging resistance to amphotericin B, nystatin, and flucytosine warrants attention.
- Continued monitoring of antifungal susceptibility patterns is essential for managing vaginal candidiasis.