Related Experiment Videos
Dorsal root ganglion proteins in Friedreich's ataxia
J R Small1, P K Thomas, A H Schapira
1Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
Neuroscience Letters
|December 12, 1993
Abstract:
The polypeptide composition of dorsal root ganglia from 8 human controls, 6 Friedreich's ataxia (FA) patients and 1 patient with diabetic neuropathy was studied by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis (PAGE). Silver-stained gels demonstrated a decrease in a 40-kDa protein in FA patients. This protein appeared to be present in normal amounts in the diabetic ganglion, suggesting that this 40-kDa protein deficiency was not simply a reflection of reduced neuronal numbers but may be specific for FA.