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Cis-hydroxyproline inhibits adhesion, migration and proliferation of cultured rabbit keratocytes
S Saika1, O Yamanaka, N Hashizume
1Department of Ophthalmology, Wakayama Medical College, Japan.
Ophthalmic Research
|January 1, 1993
Abstract:
Recruitment of keratocytes into injured corneal stroma, and secretion of proteins including collagen in the cells are essential for wound healing of the corneal stroma. We examined the effect of a proline analog, cis-hydroxyproline, on the adhesion, migration and growth of rabbit keratocytes in vitro. This agent decreased the plating efficiency, migration and growth of the keratocytes in a dose-dependent manner. Reduction in these cellular activities may reflect altered functions of pericellular proteins such as collagen. Further studies are needed to determine which specific protein is involved.