[Current possibilities of malaria chemoprophylaxis]

The number of chloroquine-resistant Pl. falciparum malaria cases in the last decade dramatically increased. This fact causes significant problems not only in the therapy but in the malaria chemoprophylaxis as well. Presently, in accordance with the WHO's recommendations, the drug of choice in the malaria chemoprophylaxis is mefloquine. Other drugs can be used only when there is a problem (medical or other) in mefloquine-use. Halofantrine (Halfan) or the so-called "double-acting" drugs (e.g. Fansidar) are not recommended in the malaria chemoprophylaxis.