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Related Experiment Videos

Prostatectomy in factor XI deficiency

J M Kaufman

    The Journal of Urology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Factor XI deficiency, a rare bleeding disorder, presents unique challenges in urologic surgery. Patients undergoing prostatectomy experienced significant postoperative bleeding, with fresh frozen plasma showing variable efficacy.

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    Area of Science:

    • Urology
    • Hematology
    • Coagulopathy

    Background:

    • Factor XI deficiency is an uncommon inherited bleeding disorder.
    • It is characterized by bleeding after surgery or trauma, despite no prior bleeding history.
    • This condition has not been previously reported in urologic patients.

    Observation:

    • Four patients with factor XI deficiency underwent open prostatectomy.
    • All patients experienced excessive postoperative bleeding and prolonged hospitalization.

    Findings:

    • Fresh frozen plasma controlled bleeding in three patients.
    • One patient developed congestive heart failure due to fluid overload from fresh frozen plasma.
    • The fourth patient had severe bleeding refractory to fresh frozen plasma, requiring extensive transfusions and procedures.

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    Implications:

    • Factor XI deficiency poses significant risks for urologic surgical patients.
    • Management requires careful consideration of fresh frozen plasma risks and benefits.
    • Alternative strategies may be needed for refractory bleeding cases in urologic surgery.