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Factors affecting circulating growth hormone binding protein in chickens
E T Tobar-Dupres1, D P Froman, S L Davis
1Department of Animal Sciences, Oregon State University, Corvallis 97331.
Poultry Science
|December 1, 1993
Summary
Serum growth hormone binding protein (GHBP) in chickens decreases with age and is affected by feed deprivation. Nutritional status and cortisone acetate did not significantly alter GHBP levels in this study.
Area of Science:
- Animal Endocrinology
- Poultry Physiology
- Biochemical Regulation
Background:
- Growth hormone binding protein (GHBP) may reflect hepatic growth hormone receptor (GHR) activity.
- Understanding factors influencing GHBP is crucial for growth regulation studies.
Purpose of the Study:
- To investigate the impact of age, sex, nutritional status, and glucocorticoids on chicken serum GHBP concentrations.
- To assess the potential of GHBP as a noninvasive indicator of GHR status.
Main Methods:
- Serum GHBP activity (%SB) was measured across different ages (hatch to 5 weeks).
- Effects of short-term nutrient deprivation, refeeding, low-protein diets, and cortisone acetate administration were evaluated.
- Sex-related differences were analyzed.
Main Results:
- Serum GHBP activity was highest at hatch and decreased linearly with age.
- Short-term (24-h) nutrient deprivation significantly reduced GHBP activity, which normalized upon refeeding.
- No significant differences in GHBP were observed based on sex, low-protein diet, or cortisone acetate treatment.
Conclusions:
- Serum GHBP in chickens is significantly influenced by age and feed deprivation.
- Further research is needed to correlate these GHBP changes with GHR status, as seen in mammals.