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Concurrent acute exercise alters central and peripheral responses to physostigmine
S N Dube1, S M Somani, S R Babu
1Southern Illinois University, School of Medicine, Department of Pharmacology, Springfield 62794-9230.
Pharmacology, Biochemistry, and Behavior
|December 1, 1993
Summary
Physostigmine and acute exercise alter cholinesterase activity and recovery. Exercise alone boosts red blood cell cholinesterase, while physostigmine decreases it, with combined effects varying by tissue.
Area of Science:
- Biochemistry
- Exercise Physiology
- Pharmacology
Background:
- Cholinesterase (ChE) is crucial for neurotransmission.
- Physostigmine (Phy) is a ChE inhibitor.
- Acute exercise impacts physiological processes.
Purpose of the Study:
- To investigate the combined effects of physostigmine and acute exercise on ChE activity and recovery.
- To determine the time course of ChE decarbamylation and recovery.
- To examine tissue-specific responses to Phy and exercise.
Main Methods:
- Rats were administered physostigmine.
- Concurrent acute exercise at 80% VO2-max was performed.
- ChE activity, decarbamylation rate (Kd), and recovery half-time were measured in RBC and tissues.
Main Results:
- Acute exercise transiently increased RBC ChE activity.
- Physostigmine decreased ChE activity in RBC and tissues.
- Combined Phy and exercise significantly increased Kd in RBC, brain, and heart.
- Kd decreased in diaphragm and muscle compared to Phy alone.
Conclusions:
- Concurrent acute exercise modulates physostigmine's effects on ChE activity and recovery.
- Tissue-specific variations in Kd suggest altered Phy redistribution due to exercise-induced blood flow changes.
- This interaction has implications for understanding drug efficacy and physiological responses.