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Inhibition of nitric oxide (NO) production selectively impairs learning and memory in the rat
L B Estall1, S J Grant, G A Cicala
1Department of Psychology, University of Delaware, Newark 19716.
Pharmacology, Biochemistry, and Behavior
|December 1, 1993
Abstract:
Animals administered the nitric oxide (NO) synthase inhibitor N-w-nitro-L-arginine methyl ester (NAME) for five days exhibited severe deficits in acquisition of a place-navigation learning task. The effect of NAME was selective to place-navigation learning. NAME had no effect on sensorimotor or motivational processes in a related task. These results are consistent with the view that NO participates in learning and execution of memory tasks.