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Updated: Aug 11, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 4, 2015
Stable chromosome aberrations 25 years after severe accidental radiation exposure
A Maes1, A Hilali, E D Léonard
1Vlaamse Instelling voor Technologisch Onderzoek (V.I.T.O.), Division of Environmental Research, Mol, Belgium.
Abstract:
A thorough cytogenetic analysis using G-banding was performed on 100 peripheral blood lymphocytes from an individual who had been accidentally exposed to radiation more than 25 years previously. More than 60% of the analysed cells were found to possess one or more stable chromosome aberrations (e.g. reciprocal translocations). Chromosomes 1 and 11 were more involved in these aberrations than would be expected from the relative chromosome lengths. No identical stable aberrations were found, suggesting that, 25 years after near-lethal exposure, haemopoietic stem cells display substantial diversity.
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