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Sneddon's syndrome with anticardiolipin antibodies--complications and treatment

B P Lotz1, C M Schutte, P F Colin

  • 1Department of Neurology, University of Pretoria.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|September 1, 1993
PubMed

Insights

Sneddon's syndrome, a rare disorder, involves blood clots and organ damage. Early treatment with immunosuppressants and anticoagulants can prevent severe complications like stroke and improve kidney function.

Area of Science:

  • Neurology
  • Rheumatology
  • Cardiology

Background:

  • Sneddon's syndrome is a rare, chronic condition characterized by non-inflammatory occlusive hydrocephalus and multiple neurological events.
  • Anticardiolipin antibodies are associated with an increased risk of thrombosis and pregnancy complications.

Observation:

  • Two patients with Sneddon's syndrome presented with elevated anticardiolipin antibodies.
  • Systemic complications included stroke, recurrent pregnancy loss, cardiac valvular disease, acrocyanosis, hypertension, and renal insufficiency.

Findings:

  • Treatment with a combination of immunosuppressive agents and anticoagulants (warfarin or aspirin) was initiated.
  • This therapeutic approach prevented further systemic complications and led to improved renal function in both patients.

Implications:

  • Sneddon's syndrome, despite its rarity, is a potentially treatable condition requiring multidisciplinary awareness.
  • Early diagnosis and management are crucial for preventing severe systemic morbidity and improving patient outcomes.

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