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Distribution and elimination of ingested brevetoxin (PbTx-3) in rats
1Department of Pathology, Ontario Veterinary College, University of Guelph, Canada.
Abstract:
As a first step towards understanding the pathologic effects of ingested brevetoxin (PbTx) in marine mammals, we determined how [3H]PbTx-3 was distributed and eliminated when ingested at sub-lethal dosages (18.6 micrograms/kg) by Fischer 344 rats. Brevetoxin was distributed widely in the body, but concentrated primarily in the liver. It was eliminated in equivalent quantities through the urine and feces. However, we believe urinary clearance is the primary route for PbTx-3 absorbed from the gastrointestinal tract.