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Genotoxicity of tritiated water in human lymphocytes
G Ribas1, E Carbonell, N Xamena
1Departament de Genética i de Microbiologia, Facultat de Ciènces, Universitat Autónoma de Barcelona, Cerdanyola de Vallès, Spain.
Toxicology Letters
|January 1, 1994
Abstract:
The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that beta-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE.