[Clinico-morphological comparisons in patients with chronic glomerulonephritis and elevated arterial pressure]

The study assessed functional condition and restructuring of renal tissues, correlations between some clinical and morphological parameters in 250 patients suffering from chronic glomerulonephritis (CGN) with secondary hypertension (SH) and in 47 CGN patients with isolated urinary syndrome (IUS). Mesangioproliferative glomerulonephritis (MSPG) was diagnosed in 173 patients (143 with SH, 30 with IUS), membrano-proliferative glomerulonephritis (MPG) in 69 (56 with SH and 13 with IUS), membranous glomerulonephritis in 37 patients (33 with SH, 4 with IUS), focal-segmentary with SH in 11 and minimal glomerulonephritis in 7 patients. The comparison revealed significant differences in arterial pressure (AP) and more severe renal lesions in SH than in IUS. The analysis of renal tissue restructuring showed SH patients to develop vascular and tubulointerstitial disorders along with glomerular hyalinosis indicative of AP rise with progressing sclerotic involvement specific for various morphological forms. This is confirmed by a significant correlation between glomerular hyalinosis and AP in MSPG with SH and MPG with SH, while in other morphological forms these are absent. The results suggest dissimilar mechanisms of SH progression in various CGN morphological patterns.