Related Experiment Videos
[Opportunistic mycotic infections in immunologically weakened patients (occurrence, risk factors, pathogenesis)]
Vnitrni Lekarstvi
|December 1, 1993
Abstract:
A permanent increase of opportunistic mycotic infections is recorded since the sixties in conjunction with new therapeutic procedures. In the submitted review the authors mention mechanisms leading to the development of systemic mycosis. They mention factors of virulence of fungi and predisposing factors which from the aspect of the macroorganism make the development of fungal infections possible.
Insights
Opportunistic fungal infections have risen since the 1960s due to new therapies. This review explores the mechanisms, fungal virulence factors, and host predisposing factors contributing to systemic mycosis development.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Immunology
Context:
- Since the 1960s, a notable increase in opportunistic mycotic infections has been observed.
- This rise correlates with advancements in therapeutic procedures and medical interventions.
Purpose:
- To review the mechanisms underlying the development of systemic mycosis.
- To identify key fungal virulence factors contributing to infection.
- To examine predisposing factors in the macroorganism that facilitate fungal infections.
Summary:
- The review details how modern medical treatments can inadvertently create conditions favoring fungal overgrowth.
- It elaborates on specific virulence attributes of fungi that enable them to cause disease.
- Predisposing host factors, such as immunosuppression or altered microbiota, are discussed as critical elements.
Impact:
- Provides a comprehensive overview of the multifactorial nature of opportunistic mycoses.
- Highlights the importance of understanding fungal pathogenesis and host susceptibility.
- Informs clinical practice regarding the prevention and management of fungal infections in vulnerable patients.