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[Epidemiologic studies of celiac disease in childhood in the Dresden district]
1Klinik und Poliklinik für Kinderheilkunde, Universitätsklinikums Carl Gustav Carus der Technischen Universität Dresden.
Insights
Celiac disease incidence in children (0-16 years) from 1970-1986 was 1:2060, with a prevalence of 44/100,000. Girls were more frequently diagnosed than boys.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Autoimmune Disorders
Context:
- Prospective study in a defined German region (Dresden) from 1970-1986.
- Utilized European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) diagnostic criteria.
- Included 399,477 live births and 170 confirmed pediatric celiac disease cases.
Purpose:
- To determine the incidence and prevalence of celiac disease in children aged 0-16 years.
- To analyze epidemiological trends of pediatric celiac disease over a 17-year period.
Summary:
- The study recorded an incidence rate of 1:2060 births.
- Prevalence in December 1986 was 44 per 100,000 children (0-16 years).
- A higher incidence was observed in girls compared to boys (1.8:1 ratio).
Impact:
- Provides crucial epidemiological data on pediatric celiac disease in Germany during the late 20th century.
- Highlights potential sex-based differences in celiac disease occurrence.
- Informs public health strategies and resource allocation for pediatric autoimmune conditions.
Abstract:
The incidence and prevalence of celiac disease in children aged 0-16 years during the years 1970-1986 have been studied prospectively in a geographic defined area of Germany. The celiac disease has been diagnosed due to the criteria of ESPGAN. During the mentioned time period, 170 patients with confirmed celiac disease and 399,477 live births were registered. This corresponds to an incidence of 1:2060. In December 1986 384,840 children in the age between 0 and 16 years were living in the region of Dresden. This corresponds to a prevalence of 44/100,000 inhabitants. Girls were more often affected than boys (1.8:1).