Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrous oxide uptake during spontaneous and controlled ventilation

J P Bengtson1, A Bengtsson, O Stenqvist

  • 1Department of Anaesthesia and Intensive Care, Sahlgren Hospital, University of Göteberg, Sweden.

Anaesthesia
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of disorder-free localization using a (2+1)D lattice gauge theory on a quantum processor.

Science (New York, N.Y.)·2026
Same author

Clinical and histopathological features of a population-based cohort of 95 consecutive patients with immunoglobulin G4-related disease in Stockholm, Sweden, during a five-year period.

Scandinavian journal of rheumatology·2026
Same author

Visualizing dynamics of charges and strings in (2 + 1)D lattice gauge theories.

Nature·2025
Same author

Scaling and logic in the colour code on a superconducting quantum processor.

Nature·2025
Same author

Thermalization and criticality on an analogue-digital quantum simulator.

Nature·2025
Same author

Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms.

BMC rheumatology·2025

Nitrous oxide uptake in anesthesia was studied. Uptake rates followed the square root of time concept and were similar regardless of anesthetic agent or ventilation method.

Area of Science:

  • Anesthesiology
  • Pharmacokinetics
  • Respiratory Physiology

Background:

  • Nitrous oxide is a common anesthetic gas.
  • Understanding its uptake is crucial for optimizing anesthetic delivery.
  • Factors like ventilation mode and anesthetic agents may influence uptake.

Purpose of the Study:

  • To investigate the rate of nitrous oxide uptake in orthopedic patients.
  • To compare uptake between enflurane and isoflurane anesthesia.
  • To evaluate the effect of spontaneous versus controlled ventilation on nitrous oxide uptake.

Main Methods:

  • Studied 40 orthopedic patients under anesthesia.
  • Utilized enflurane or isoflurane with nitrous oxide.
  • Employed a modified Douglas bag method with low fresh gas flows.

Related Experiment Videos

  • Compared spontaneous and controlled ventilation techniques.

    • Main Results:

    • No significant differences in nitrous oxide uptake were observed between anesthetic groups.
    • Uptake rates followed the 'square root of time concept'.
    • Overall best fit curve for uptake: 1080.t-0.505 ml.70 kg-1 x min-1.
    • Spontaneous ventilation showed similar or higher nitrous oxide uptake rates compared to controlled ventilation, despite lower minute volumes.

    Conclusions:

    • Anesthetic agent (enflurane vs. isoflurane) and ventilation mode (spontaneous vs. controlled) do not significantly alter nitrous oxide uptake rates.
    • The square root of time model accurately describes nitrous oxide uptake kinetics.
    • Higher uptake during spontaneous ventilation may be attributed to factors beyond minute volume.