Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Is urapidil a venodilator?]

J Y Lepage1, J M Malinovsky, C De Dieuleveult

  • 1Département d'Anesthésie et de Réanimation Chirurgicale, Hôtel-Dieu, CHU, Nantes.

Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can local vibration alter the contribution of persistent inward currents to human motoneuron firing?

The Journal of physiology·2023
Same author

[Proposal of guidelines for antibiotic prophylaxis in plastic, reconstructive, and aesthetic surgery].

Annales de chirurgie plastique et esthetique·2019
Same author

Safety of subsequent general anaesthesia in patients allergic to neuromuscular blocking agents: value of allergy skin testing.

British journal of anaesthesia·2018
Same author

Hemodynamic monitoring by the aortic velocity-time integral in supra sternal Doppler echocardiography and total cavo-pulmonary derivation in cesarean delivery.

Journal of clinical anesthesia·2018
Same author

Disseminated intravascular coagulation syndrome two months after conservative management of placenta accreta. About two patients.

European journal of obstetrics, gynecology, and reproductive biology·2017
Same author

Time to achieve target mean arterial pressure during resuscitation from experimental anaphylactic shock in an animal model. A comparison of adrenaline alone or in combination with different volume expanders.

Anaesthesia and intensive care·2013
Same journal

Annales francaises d'anesthesie et de reanimation·2020
Same journal

[Multimodal approach to enhance filter lifespan: are all actions equal?].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Disparity of French Emergency medical services equipment: disparity of funding allocation or of management quality?].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Eligibility to a Maastricht III - type organ donation according to the protocol proposed by the French organ procurement organization (Agence de la biomedicine) among patients in a medico surgical intensive care unit].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Enhanced recovery after elective colorectal surgery: reply].

Annales francaises d'anesthesie et de reanimation·2014
Same journal

[Aorto-right atrial fistula as complication of aortic dissection].

Annales francaises d'anesthesie et de reanimation·2014
See all related articles

Urapidil and clonidine effectively reduced blood pressure in hypertensive patients without compromising right ventricular function. Both drugs maintained right ventricular ejection fraction while decreasing ventricular volumes.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Essential hypertension and coronary artery disease pose significant cardiovascular risks.
  • Assessing the impact of antihypertensive agents on right ventricular function is crucial for patient management.

Purpose of the Study:

  • To compare the effects of urapidil and clonidine on right ventricular (RV) volumes and function.
  • To evaluate RV performance in patients with essential hypertension and coronary artery disease.

Main Methods:

  • 20 ASA III patients with essential hypertension were randomized to receive urapidil or clonidine.
  • Hemodynamic parameters, including RV volumes and ejection fraction, were monitored using Swan-Ganz catheterization.
  • Plasma atrial natriuretic factor levels were measured.

Related Experiment Videos

Main Results:

  • Both urapidil and clonidine reduced mean arterial pressure significantly in supine and tilted positions.
  • Neither drug altered heart rate or peripheral vascular resistance.
  • Right ventricular ejection fraction was preserved, while end-diastolic and end-systolic volumes decreased.

Conclusions:

  • Urapidil and clonidine demonstrate similar efficacy in reducing blood pressure.
  • Both agents maintain right ventricular ejection fraction and decrease RV volumes in hypertensive patients.
  • These findings suggest a favorable hemodynamic profile for both drugs in this patient population.