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[Application of monoclonal antibody for cancer therapy]
1First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 1, 1994
Abstract:
Immunoconjugates composed of mouse monoclonal antibody and anticancer drug was applied for the treatment of patients with colorectal cancer. Administration of mouse antibody raised human anti-mouse antibody that may interfere with the effect of immunoconjugates. To resolve this problem, human/mouse chimeric antibody was prepared and immunoconjugate of chimeric antibody and anticancer drug was developed. The characteristics of this new immunoconjugate were described.