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Acute systemic hypoxia and the surface ultrastructure and morphological characteristics of rat leucocytes
R Mian1, D Westwood, P Stanley
1Department of Physiology, Medical School, University of Birmingham.
Experimental Physiology
|November 1, 1993
Abstract:
We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the appearance of crater-like holes, a reduction in granule size and disruption of the cell membrane. The implications of these findings are discussed.