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Related Experiment Videos

Static left latissimus dorsi cardiomyoplasty: effect on left ventricular function

R R Lazzara1, S E Park, B L Cmolik

  • 1Department of Surgery, Allegheny General Hospital, Pittsburgh, PA 15212.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|November 1, 1993
PubMed
Summary

Static cardiomyoplasty using the latissimus dorsi muscle does not immediately impair left ventricular function. This surgical approach shows no significant changes in systolic or diastolic function in canine hearts, offering a potentially safe initial step.

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Area of Science:

  • Cardiovascular Surgery
  • Surgical Techniques
  • Cardiac Function Analysis

Background:

  • Latissimus dorsi cardiomyoplasty is a procedure for ventricular augmentation.
  • A delay is typically required for muscle revascularization and adaptation.
  • The immediate effects of static (unstimulated) cardiomyoplasty are not well understood.

Purpose of the Study:

  • To analyze the immediate effect of static latissimus dorsi cardiomyoplasty on left ventricular function.
  • To assess changes in systolic and diastolic parameters before and after the procedure.

Main Methods:

  • Four mongrel dogs underwent staged left latissimus dorsi cardiomyoplasty.
  • Left ventricular pressure and volume were measured using micromanometer catheter and sonomicrometry.

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  • Key functional parameters including cardiac output, stroke work, and relaxation constants were evaluated.

    • Main Results:

    • No significant differences were observed in systolic function indexes (e.g., stroke work, cardiac output).
    • Diastolic function parameters (e.g., end-diastolic volume, relaxation constant) remained unchanged.
    • Heart rate and other measured hemodynamic variables showed no significant alterations immediately post-procedure.

    Conclusions:

    • Static latissimus dorsi cardiomyoplasty can be performed with minimal immediate impact on left ventricular systolic and diastolic function.
    • This suggests that the initial phase of this procedure is hemodynamically stable in a healthy canine model.
    • Further research may explore the long-term effects and benefits of this technique.