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Related Experiment Videos

Hypertension after lung transplantation

R J Morrison1, H D Short, G P Noon

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|November 1, 1993
PubMed
Summary

Hypertension affects 66% of lung transplant recipients, developing a mean of 11 months post-transplant. Cyclosporine and renal function did not predict its onset, suggesting unique mechanisms in lung transplant patients.

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Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation Immunology

Background:

  • Hypertension is a known side effect of cyclosporine, a common immunosuppressant.
  • The incidence of hypertension post-lung transplantation is not well-documented.
  • Cyclosporine is used in various organ transplantations, including kidney, heart, and bone-marrow.

Purpose of the Study:

  • To determine the incidence of hypertension in lung transplant recipients.
  • To investigate potential causes of post-transplant hypertension in this population.
  • To compare hypertension incidence in lung transplant recipients with other organ transplant recipients.

Main Methods:

  • Retrospective review of 21 previously normotensive lung transplant recipients.
  • Analysis of incidence, onset time, and potential contributing factors like renal function and cyclosporine levels.

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  • Comparison with existing data from kidney, heart, and bone-marrow transplant recipients.

    • Main Results:

    • Hypertension developed in 14 of 21 patients (66%), with a mean onset of 11 months post-transplant.
    • Renal function was diminished in all patients; however, neither renal function nor cyclosporine levels predicted hypertension development.
    • Incidence was comparable to kidney (67%) and bone-marrow (60%) recipients, but lower than heart recipients (90%).

    Conclusions:

    • Lung transplant recipients experience a high incidence of hypertension, similar to other solid organ transplants.
    • The delayed onset and lack of correlation with renal function or cyclosporine levels suggest unique pathophysiological mechanisms in lung transplantation.
    • Preserved cardiac innervation may contribute to a lower incidence compared to heart transplant recipients.