Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional significance of the A-current

B Gerber1, E Jakobsson

  • 1Biology Honors Program, University of Illinois, Urbana 61801.

Biological Cybernetics
|January 1, 1993
PubMed
Summary

This study simulated synaptic inputs on an excitable membrane model, finding that inhibition significantly narrows the range of elicited action potential frequencies. The A-current

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of mitral valve regurgitation in 102 apparently healthy Dachshunds.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2026
Same author

[Bacteria species and antibiotic resistance in bovine mastitis within the framework of the «ReLait» project].

Schweizer Archiv fur Tierheilkunde·2025
Same author

Co-designing interprofessional education in primary healthcare: an illustration from the Make My Day stroke prevention project.

Journal of interprofessional care·2025
Same author

Correction to: Two-stage laparoscopic transversus abdominis plane block as an equivalent alternative to thoracic epidural anaesthesia in bowel resection-an explorative cohort study.

International journal of colorectal disease·2024
Same author

Two-stage laparoscopic transversus abdominis plane block as an equivalent alternative to thoracic epidural anaesthesia in bowel resection-an explorative cohort study.

International journal of colorectal disease·2024
Same author

Distribution of normalized pulmonary transit time per pathology in a population of routine CMR examinations.

The international journal of cardiovascular imaging·2023

Area of Science:

  • Computational neuroscience
  • Biophysics
  • Mathematical modeling

Background:

  • Hodgkin-Huxley type models are fundamental to understanding neuronal excitability.
  • The A-current plays a role in shaping neuronal firing patterns.
  • Simulating synaptic inputs offers a more biologically realistic approach than injected currents.

Purpose of the Study:

  • To investigate the response of an excitable membrane model with A-current to simulated synaptic inputs.
  • To compare these responses with simulations using injected currents.
  • To elucidate the influence of synaptic inhibition on action potential generation.

Main Methods:

  • Utilized a Hodgkin-Huxley type excitable membrane model.
  • Incorporated sodium, delayed-rectifier potassium, and A-current channels.
  • Simulated both excitatory and inhibitory synaptic inputs.
  • Compared results with previous simulations using injected currents.

Main Results:

  • Synaptic stimuli, unlike injected currents, alter membrane resistance, affecting model response.
  • The A-current had minimal impact on oscillation frequency across most synaptic input ranges.
  • A delay in spiking onset was observed, correlated with A-current inactivation time.
  • Substantial inhibition abolished very-low-frequency spiking and narrowed the overall frequency range elicitable by excitation.

Conclusions:

  • Synaptic inhibition critically restricts the range of firing frequencies in excitable models.
  • The presence of inhibition can prevent spiking entirely, regardless of excitation levels.
  • Model behavior under synaptic input differs from injected current due to changes in membrane resistance.

Related Experiment Videos