[The effect of lipid peroxidation-modified lipoproteins on thrombocyte aggregation]

Platelet aggregation induced by native and oxidized low-density lipoproteins (LDL) was studied. The minimal LDL concentration necessary for platelet activation was no more than 0.2 mg/ml. The aggregation rate increased when LDL concentration rose from 0 to 0.4-0.6 mg/ml for native LDL and to 0.2-0.4 mg/ml for oxidized LDL. The platelet aggregation induced by oxidized LDL appeared to be higher than that induced by the same concentration of native LDL. The dependence of aggregation rate on the degree of LDL peroxidation was linear up to MDA concentration equal to 3-4 mg/ml. Further LDL peroxidation leads only to the negligible increase in the induced aggregation rate.