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[Effect of Japanese Ganoderma Lucidum on production of interleukin-2 from murine splenocytes]
The purpose of this study was to determine the effect of Ganoderma lucidum (GL) planted in Japan on the production of Interleukin-2 (IL-2) from murine splenocytes. It was observed that hydrocortisone (HC) 0.025-1 microgram /ml could significantly antagonize the inhibitory activity of HC and CSA to increase the production of IL-2 in vitro, P < 0.01. When the splenocytes pretreated with GL alone or in combination with HC, it was shown that pretreatment alone had no significant effect on IL-2 production, but preincubating splenocytes with HC and GL resulted in a significant increase of IL-2 production when compared with that of HC group, P < 0.01. In vivo, GL 300 mg/kg could increase the production of IL-2 when oral taken GL alone or in combination of HC.
The purpose of this study was to determine the effect of Ganoderma lucidum (GL) planted in Japan on the production of Interleukin-2 (IL-2) from murine splenocytes. It was observed that hydrocortisone (HC) 0.025-1 microgram /ml could significantly antagonize the inhibitory activity of HC and CSA to increase the production of IL-2 in vitro, P < 0.01. When the splenocytes pretreated with GL alone or in combination with HC, it was shown that pretreatment alone had no significant effect on IL-2 production, but preincubating splenocytes with HC and GL resulted in a significant increase of IL-2 production when compared with that of HC group, P < 0.01. In vivo, GL 300 mg/kg could increase the production of IL-2 when oral taken GL alone or in combination of HC.