Vasodilating effect of dipyridamole on rat endoneurial vessels: morphometric study

Ischaemia plays an important role in the pathogenetic mechanism of various neuropathies. To study the possible vasodilating effects of dipyridamole on peripheral nerve vessels, morphometric analysis of endoneurial vessels was undertaken in rat sciatic and tibial nerves after chronic dipyridamole treatment. Each rat was injected with 4 mg/kg of dipyridamole intraperitoneally twice daily for 5 days/week and once daily during the weekend for a period of 6 weeks. The mean luminal area and perimeter of endoneurial vessels in the sciatic nerve were significantly greater in dipyridamole-treated animals than in controls. The total fascicular area and densities of endoneurial vessels were not significantly different between experimental and control groups. This study demonstrated that daily administration of dipyridamole over a 6 week period caused endoneurial vessels to dilate resulting in increased luminal area and perimeter. Dipyridamole might be a potent therapeutic agent for peripheral neuropathies attributed to nerve ischaemia.