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Serum protein concentration during hemorrhagic shock

L C Getzen, E W Pollak, E F Wolfman

    Surgery, Gynecology & Obstetrics
    |January 1, 1977
    PubMed
    Summary

    Serum albumin levels drop rapidly during hemorrhagic shock, indicating early leakage into tissues. Prompt infusion of large molecules may help restore critical fluid balance.

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    Area of Science:

    • Physiology
    • Biochemistry
    • Emergency Medicine

    Background:

    • Hemorrhagic shock leads to complex physiological changes.
    • Understanding early serum protein shifts is crucial for timely intervention.

    Purpose of the Study:

    • To evaluate early alterations in serum protein concentrations post-hemorrhage.
    • To investigate the behavior of albumin and globulin fractions during shock.

    Main Methods:

    • Analysis of serum protein and hematocrit in 20 dogs after massive bleeding.
    • Monitoring changes at 15 and 45 minutes post-hemorrhage.

    Main Results:

    • Serum protein concentration decreased faster than hematocrit within 15 minutes.
    • Albumin showed the most significant early decrease, suggesting interstitial leakage.
    • Globulin levels remained more stable, indicating less consistent interstitial loss.

    Conclusions:

    • Early albumin loss occurs rapidly in hemorrhagic shock due to increased capillary permeability.
    • Intravenous infusion of macromolecules larger than albumin is recommended to counteract oncotic gradient reduction.

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