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Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons
D S Magnuson1, W A Staines, K C Marshall
1Department of Physiology, University of Ottawa, Ont., Canada.
Brain Research
|November 19, 1993
Abstract:
The electrophysiological characteristics of intracellularly recorded locus coeruleus (LC) neurons in brain stem slices from DSP-4 treated animals have been compared to those from untreated controls. LC neurons from DSP-4 treated animals had action potentials and Ca2+ spikes (elicited in the presence of TTX) of significantly reduced duration compared to controls. These observations suggest that chemical axotomy with DSP-4 reduces Ca2+ conductance in neurons of the locus coeruleus.