[Aluminium toxicity to bone of rabbits]

Rabbits were used to study the toxic effects of A1 on their skeleton. The A1 content in bone, serum A1 content and PTH level were increased along with A1 intake increase, and there was positive correlation between them (P < 0.01). Bone Ca and P contents were increased with A1 intake increase, but serum Ca level was decreased. Pathological examination of decalcified bone sections revealed no apparent changes between test and control groups. Histomorphometric results of undecalcified bone sections showed that osteoid of low and high A1 intake groups tended to increase, mineralization process of high A1 intake group was inhibited, and bone tissue formation of low A1 intake group tended to increase.