Reversible monoamine oxidase-A inhibitors in social phobia

Placebo-controlled studies of standard and reversible monoamine oxidase-A (MAO-A) inhibitors in social phobia are reviewed. Four studies utilized several common measures, including the Liebowitz Social Anxiety Scale and the Hamilton Anxiety Scale. Efficacy for phenelzine, moclobemide, and brofaromine appeared comparable across studies on both categorical and dimensional measures, as did placebo results. In terms of patient characteristics, baseline social phobia ratings were similar across studies, but initial Hamilton Anxiety Scale scores differed. Although the reason for this is uncertain, it is more likely due to rater differences than to patient differences.