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Hypersensitivity to topical corticosteroids

S M Wilkinson1

  • 1Skin Hospital, Manchester, UK.

Clinical and Experimental Dermatology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Topical corticosteroid hypersensitivity is increasingly recognized, affecting 2-5% of patients with contact dermatitis. A specific corticosteroid series effectively detects most cases, aiding diagnosis in various dermatitis types.

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Area of Science:

  • Dermatology
  • Allergology
  • Clinical Immunology

Background:

  • Contact hypersensitivity to topical corticosteroids is a growing concern.
  • It affects 2-5% of patients presenting to contact dermatitis clinics.
  • Hypersensitivity is prevalent in stasis dermatitis but also common in other dermatitis types.

Purpose of the Study:

  • To highlight the increasing recognition of contact hypersensitivity to topical corticosteroids.
  • To present diagnostic methods for corticosteroid hypersensitivity.
  • To discuss the prevalence and affected patient populations.

Main Methods:

  • Utilized a corticosteroid series including tixocortal pivalate and other steroids for detection.
  • Employed petrolatum and ethanol bases for topical application.

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  • Considered intradermal tests for selected challenging cases.

    • Main Results:

    • The corticosteroid series successfully detects the majority of hypersensitivity cases.
    • Corticosteroid hypersensitivity is frequent in stasis dermatitis and comparable to other common allergens in other dermatitis types.
    • Reactions can occur via topical, mucosal, systemic, or sex steroid exposure.

    Conclusions:

    • Contact hypersensitivity to topical corticosteroids is an under-recognized condition.
    • Standardized corticosteroid patch testing is effective for diagnosis.
    • Awareness and diagnostic vigilance are crucial for managing corticosteroid hypersensitivity across various clinical presentations.