Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhalational lung injury causing bronchiolitis

J L Wright1

  • 1Department of Pathology, University of British Columbia Faculty of Medicine, Vancouver, Canada.

Clinics in Chest Medicine
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Improving cosmological reach of a gravitational wave observatory using Deep Loop Shaping.

Science (New York, N.Y.)·2025
Same author

Corrigendum to "Nomogram Predicting Bladder Cancer-specific Mortality After Neoadjuvant Chemotherapy and Radical Cystectomy for Muscle-invasive Bladder Cancer: Results of an International Consortium" [Eur Urol Focus 2021;7:1347-54].

European urology focus·2022
Same author

Mentoring from the diverse lens of epidemiologists reveals a dynamic and mutually rewarding relationship.

Annals of epidemiology·2021
Same author

Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

Living reviews in relativity·2020
Same journal

Pneumonia Reimagined: Host, Microbe, and the Shifting Landscape of Disease.

Clinics in chest medicine·2026
Same journal

Advocacy in Pneumonia.

Clinics in chest medicine·2026
Same journal

Vaccines Against Pneumonia: Current Updates.

Clinics in chest medicine·2026
Same journal

Non-antibiotic Treatments for Pneumonia: Host-Directed Therapies, Next-Steps and Future Directions.

Clinics in chest medicine·2026
Same journal

Customizing Antibiotic Treatment for Pneumonia: Can We Have a Single Unified Algorithm for All Types of Pneumonia?

Clinics in chest medicine·2026
Same journal

The Role of Complex Digital Interventions to Improve Pneumonia Care.

Clinics in chest medicine·2026
See all related articles

Inhalational injury to the respiratory tract causes subtle yet common damage. Inflammation and fibrosis are likely nonspecific responses, leading to similar airway distortion regardless of the inhaled agent.

Area of Science:

  • Pulmonary Medicine
  • Toxicology
  • Pathology

Background:

  • Inhalational injuries to the respiratory tract are frequent and often present subtly.
  • Clinical manifestations and pulmonary function tests (typically showing an obstructive profile) are highly similar across different types of inhalational injuries.
  • Pathological examination reveals airway distortion due to inflammation and fibrosis as a common outcome.

Purpose of the Study:

  • To investigate the nature of the respiratory tract's response to various inhaled agents.
  • To determine if specific airway responses exist for different injurious agents or if the responses are generalized.
  • To elucidate the underlying mechanisms of airway distortion following inhalational injury.

Main Methods:

  • Review of clinical presentations of inhalational injuries.

Related Experiment Videos

  • Analysis of pulmonary function test results.
  • Examination of pathological findings in affected airways.

    • Main Results:

    • Clinical features of inhalational injuries are remarkably similar.
    • Pulmonary function tests consistently demonstrate an obstructive pattern.
    • Pathological changes consistently involve airway distortion, inflammation, and fibrosis.

    Conclusions:

    • The observed inflammation and fibrosis represent a nonspecific, stereotypic response of the airways to a wide range of inhaled agents.
    • It is unlikely that distinct airway responses occur for each specific injurious agent.
    • Airway distortion is a common endpoint resulting from these generalized inflammatory and fibrotic processes.