[A preliminary report on the treatment of climacteric symptoms with Org OD14]

Climacteric symptoms were treated with Org OD14 in 30 women. Each patient received 2.5 mg/day orally, for 90 consecutive days in 6 cases and 120 consecutive days in 24 cases. The results demonstrated a good clinical effect with a significant difference in Kupperman's score is 26.67 +/- 9.97 t 5.06 +/- 3.95 before and after treatment. The fasting urinary calcium/creatinine and urinary hydroxyproline/creatinine ratios, blood triglyceride and cholesterol levels decreased, vaginal cytology showed estrogenic effects during therapy. In 2 of 20 patients the endometrium changed from atrophic before treatment to slightly proliferative phase after treatment. The clinical use of org OD14 for perimenopaused women was discussed.