Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Second look in colorectal surgery

L Bucci1, G Benassai, G A Santoro

  • 1Department of General Surgery II, University of Naples, School of Medicine, Italy.

Diseases of the Colon and Rectum
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Copy-paste surgery: Altemeier procedure in identical twins with rectal prolapse.

Techniques in coloproctology·2026
Same author

Reliability of clinical examination for the assessment of obstetric anal sphincter injuries. A comparative study with 3D endoanal ultrasonography.

European journal of obstetrics, gynecology, and reproductive biology·2024
Same author

Sclerotherapy for hemorrhoidal disease: systematic review and meta-analysis.

Techniques in coloproctology·2024
Same author

MRI template to standardize reporting of anal fistula.

Techniques in coloproctology·2022
Same author

Magnetic resonance imaging template to standardize reporting of anal fistulas.

Techniques in coloproctology·2021
Same author

Impact of COVID-19 on urgent surgical activity.

The British journal of surgery·2020
Same journal

A Penny for Your Thoughts.

Diseases of the colon and rectum·2026
Same journal

June 2026 Translations.

Diseases of the colon and rectum·2026
Same journal

Selected Abstracts.

Diseases of the colon and rectum·2026
Same journal

Recurrence After Rectopexy: Insights From Magnetic Resonance Defecography.

Diseases of the colon and rectum·2026
Same journal

Risk of Metabolic Disease After Right- vs Left-Sided Colectomy for Colon Cancer: A Nationwide Cohort Study.

Diseases of the colon and rectum·2026
Same journal

Sexual Distress Is Common in Long Term Follow-up After Pelvic Pouch for Ulcerative Colitis: A Cross-Sectional Study.

Diseases of the colon and rectum·2026
See all related articles

Intensive follow-up for colorectal cancer is often unnecessary. Monitoring carcinoembryonic antigen (CEA) and instrumental restaging are useful for detecting solitary liver metastases and mucosal lesions, improving patient outcomes.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Post-operative follow-up is crucial for detecting metachronous colonic neoplasms, precancers, suture line recurrences, and isolated liver or pulmonary metastases.
  • Surgical re-resection and multimodal approaches can improve disease-free survival and quality of life for certain sites of cancer recurrence.

Purpose of the Study:

  • To evaluate the effectiveness of different follow-up plans in identifying colorectal cancer recurrence.
  • To assess the role of carcinoembryonic antigen (CEA)-directed second-look surgery in managing recurrent colorectal cancer.

Main Methods:

  • A cohort of 160 patients with radically resected Dukes B or C colorectal cancer underwent a structured follow-up protocol.
  • The protocol included plasma CEA every 2 months, echography every 6 months, chest x-ray annually, and colonoscopy at 1 year and then every 3-5 years.

Related Experiment Videos

Main Results:

  • Eighty-nine recurrences (55.6%) were detected, with 72 showing elevated plasma CEA.
  • Eight CEA-directed second-look surgeries identified recurrence in four patients, including two with resectable isolated liver metastases.
  • Symptomatic patients without CEA elevation often had unresectable diffuse disease, while solitary metastases or mucosal lesions showed potential for five-year survival.

Conclusions:

  • CEA-directed second-look surgery is not cost-effective.
  • Intensive follow-up plans may be superfluous.
  • Monitoring CEA and instrumental restaging are valuable for detecting solitary liver metastases and mucosal lesions.