Linkage detection by the Affected-Pedigree-Member method: what is really tested?
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M C Babron1, M Martinez, C Bonaïti-Pellié
1INSERM, Unité 155, Paris, France.
Genetic Epidemiology
|January 1, 1993
Abstract:
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
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