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The NHLBI male veteran twin study data
T Reed1, D Carmelli, J C Christian
1Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202.
Genetic Epidemiology
|January 1, 1993
Summary
The National Heart, Lung and Blood Institute (NHLBI) twin study investigated genetic risk factors for cardiovascular disease in male twins. It detailed sampling, zygosity, and data for Genetic Analysis Workshop 8 (GAW8).
Area of Science:
- Cardiovascular Epidemiology
- Twin Studies
- Genetics
Background:
- The National Heart, Lung, and Blood Institute (NHLBI) established a collaborative, longitudinal twin study.
- Focuses on genetic risk factors influencing cardiovascular disease (CVD) progression.
- Utilizes a cohort of 514 pairs of white, male twins, veterans of World War II and Korean War.
Purpose of the Study:
- To describe the sampling procedures and zygosity determination methods used in the NHLBI twin study.
- To report on cohort member participation across multiple examinations.
- To summarize the variables collected and prepared for the Genetic Analysis Workshop 8 (GAW8).
Main Methods:
- Longitudinal cohort design.
- Zygosity determination for twin pairs.
- Data collection and variable summarization for genetic analysis.
Main Results:
- Detailed description of sampling and zygosity determination.
- Information on cohort retention and participation rates.
- A comprehensive summary of variables available for GAW8.
Conclusions:
- The NHLBI twin study provides a valuable resource for investigating genetic influences on cardiovascular disease.
- The methodology ensures reliable data for genetic association studies.
- The prepared dataset facilitates research at GAW8.