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The stimulation by dendritic cells of host-versus-graft reactivity in vivo

S Chaudhuri1, S Chaudhuri, R Barfoot

  • 1Department of Pathology, University College of Medicine, Calcutta, India.

Immunology and Cell Biology
|December 1, 1993
PubMed

Dendritic cells (DC) isolated from peripheral intestinal lymph of inbred Wistar rats were injected into the hind footpads of Hooded CBH/Cbi rats. Administration of 10(4) and 5 x 10(5) allogeneic DC produced approximately six-fold increase in popliteal node weight. This is only marginally greater than that caused by similar doses of syngeneic DC and about 30% greater than that caused by allogeneic mononuclear cells. The data indicated that allogeneic DC were not effective stimulators of host-versus-graft reactions in this assay.

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