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Food intolerance and Crohn's disease
Gut
|June 1, 1993
Summary
Identifying food sensitivities after elemental diet for Crohn's disease (CD) remission is variable. While some patients show sensitivities, they often don't persist and don't significantly impact remission duration.
Area of Science:
- Gastroenterology
- Clinical Nutrition
- Immunology
Background:
- Crohn's disease (CD) management often involves nutritional therapy to induce remission.
- Identifying and excluding trigger foods is proposed to prolong remission after nutritional interventions.
Purpose of the Study:
- To assess the occurrence and persistence of food intolerances in Crohn's disease patients after achieving remission with an elemental diet.
Main Methods:
- 42 eligible Crohn's disease patients received an elemental diet to induce remission.
- Single foods were reintroduced over five days to identify potential triggers.
- Suspected food sensitivities were re-evaluated through open and double-blind rechallenge.
Main Results:
- 20 patients (48%) identified food sensitivities; 8 (19%) did not.
- Open rechallenge confirmed symptoms in 10 patients (24%), with 3 confirmed by double-blind challenge.
- No significant difference in remission duration was observed between patients who identified food sensitivities and those who did not.
Conclusions:
- Food sensitivities can be identified after elemental diet therapy for Crohn's disease.
- These sensitivities are often variable, may not persist, and their clinical significance is questionable for widespread elimination diets.
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