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Acute effects of conventional oral dose of disopyramide on left atrial and ventricular functions
1Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
Abstract:
Disopyramide, an antiarrhythmic drug, is known to impair cardiac function, but acute cardiac effects of conventional oral dose of disopyramide are not well known. To examine the extent of acute cardiac effects of daily oral dose of disopyramide, we gave 150 mg of disopyramide to thirteen patients with normal or impaired cardiac function, and observed cardiac function on an hourly basis for 3 hours after baseline period. The serum level of disopyramide reached a therapeutic level (2.0-5.0 micrograms/ml) mostly 1 hour after administration. Doppler-echocardiographically determined left ventricular ejection fraction, and the ratio of the peak early filling velocity to the peak atrial filling velocity in left ventricular inflow velocity remained unchanged throughout the experimental period. Other hemodynamic variables, such as blood pressure and heart rate remained unchanged. We conclude that daily oral dose of disopyramide appears to have no significant effects on cardiac function after administration. Disopyramide seems to be safe and may not be necessarily withheld from patients who need it, when hemodynamic variables are to be measured.
Insights
This study found that a standard oral dose of disopyramide (an antiarrhythmic drug) did not significantly impact cardiac function or hemodynamic variables in patients. Disopyramide appears safe for short-term use when monitoring cardiac function.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Disopyramide is an antiarrhythmic medication with known cardiac effects.
- Acute cardiac effects of conventional oral disopyramide doses are not well-established.
Purpose of the Study:
- To evaluate the acute cardiac effects of a standard daily oral dose of disopyramide.
- To assess the impact of disopyramide on cardiac function and hemodynamics in patients.
Main Methods:
- Thirteen patients received 150 mg of disopyramide orally.
- Cardiac function and hemodynamic variables were monitored hourly for 3 hours post-administration.
- Doppler echocardiography was used to assess left ventricular ejection fraction and filling velocities.
Main Results:
- Therapeutic serum levels of disopyramide were achieved within 1 hour.
- Left ventricular ejection fraction and filling velocities remained unchanged.
- Blood pressure and heart rate showed no significant alterations.
Conclusions:
- A daily oral dose of disopyramide does not appear to cause significant acute cardiac dysfunction.
- Disopyramide can be considered safe for patients needing it, even when hemodynamic monitoring is required.