Related Experiment Videos
Double-blind study to investigate methods to prevent cephalothin-induced phlebitis
American Journal of Hospital Pharmacy
|January 1, 1977
Summary
Preventing cephalothin-induced phlebitis can be achieved by adding heparin and hydrocortisone to intravenous fluids or using a 0.22-mum inline filter. These methods significantly reduced phlebitis incidence in orthopedic patients.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Patient Safety
Background:
- Cephalothin, an antibiotic, can cause phlebitis (vein inflammation) during intravenous administration.
- Phlebitis is a common complication that can lead to patient discomfort and treatment interruption.
Purpose of the Study:
- To investigate methods for preventing cephalothin-induced phlebitis.
- To evaluate the efficacy of hydrocortisone, heparin, and inline filtration in reducing phlebitis.
Main Methods:
- A randomized controlled trial involving 120 adult orthopedic patients.
- Patients received buffered cephalothin intravenously.
- Treatment groups included additions of hydrocortisone phosphate, heparin, or both, and inline filtration (0.22-mum).
Main Results:
- Significant reduction in phlebitis incidence was observed in groups receiving combined heparin and hydrocortisone.
- Inline filtration also demonstrated a significant reduction in phlebitis.
- Control group experienced higher phlebitis rates compared to specific treatment groups.
Conclusions:
- Concomitant administration of heparin and hydrocortisone with cephalothin effectively reduces postinfusion phlebitis.
- Utilizing a 0.22-mum inline final filter is a viable strategy to mitigate cephalothin-induced phlebitis.
- These interventions improve patient safety during cephalothin therapy.