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Moisture permeation of typical unit does repackaging materials

J T Reamer, L T Grady, R F Shangraw

American Journal of Hospital Pharmacy

|January 1, 1977

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This study found that common unit dose repackaging materials used by pharmacies offer limited moisture protection. Pharmacists need better awareness and standards for pharmaceutical packaging to ensure product stability.

Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Unit dose repackaging is common in hospital and community pharmacies.
Assessing the moisture permeation of these materials is crucial for drug stability.

Purpose of the Study:

To evaluate the moisture barrier properties of various unit dose repackaging materials.
To identify needs for improved pharmaceutical repackaging practices.

Main Methods:

Commercial desiccant pellets were packaged in four types of materials: polyethylene bags, PVC/paper cups, polycel-polyfoil strips, and PVC/foil blister packs.
Samples were stored at 75% relative humidity and 22°C for 4-10 days.
Weight gain was measured to assess moisture permeation.

Main Results:

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None of the tested packaging materials provided excellent moisture barrier protection.
Some materials offered temporary protection, but none were effective long-term.
Significant variation in moisture permeation was observed across different packaging types.

Conclusions:

Pharmacists require enhanced knowledge of repackaging material properties and pharmaceutical stability.
There is a need for established standards for repackaging materials and storage limits.
Guidelines and testing procedures for unit dose packaging systems are recommended.