Immunopotentiation of synthetic oligopeptides by chemical conjugation to iscoms
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M Larsson1, K Lövgren, B Morein
1National Veterinary Institute, Department of Virology, Uppsala, Sweden.
Journal of Immunological Methods
|June 18, 1993
Abstract:
A method has been devised for coupling cysteine-containing peptides to pre-formed immune stimulating complexes (iscoms). Four different peptides were used and the peptide-iscom conjugates were evaluated as immunogens in mice. It was demonstrated that highly immunogenic peptide-iscom conjugates can be prepared provided that the peptides are successfully linked to the carrier iscoms.