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Related Experiment Videos

A study of low-dose amitriptyline overdoses

J P O'Brien

    The American Journal of Psychiatry
    |January 1, 1977
    PubMed
    Summary

    A week

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    Simultaneous combined anterior and posterior fusion. A review of its concept and 10 years of refinement of the technique: a solution for the patient with severe back and leg pain.

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    Area of Science:

    • Pharmacology
    • Clinical Toxicology
    • Psychiatry

    Background:

    • Tricyclic antidepressants (TCAs) are commonly prescribed for depression.
    • A 1-week supply of TCAs is generally considered safe.
    • Concerns exist regarding the toxicity of even low-dose TCA overdoses.

    Purpose of the Study:

    • To evaluate the toxicity of low-dose amitriptyline overdoses.
    • To assess the safety of a 1-week supply of TCAs.
    • To inform prescription guidelines for TCAs.

    Main Methods:

    • Retrospective review of 12 cases of low-dose amitriptyline overdose (500-1000 mg).
    • Analysis of clinical outcomes, including severity and life-threatening events.

    Main Results:

    • Six out of 12 patients experienced life-threatening outcomes from low-dose amitriptyline overdose.
    • A 1-week supply of TCAs, previously considered safe, demonstrated severe toxicity in this cohort.

    Conclusions:

    • Low-dose amitriptyline overdose can be severely toxic and life-threatening.
    • Current prescription guidelines for TCAs may need revision.
    • Physicians should consider prescribing less than a 1-week supply for at-risk patients, particularly those with suicidal ideation.

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