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Reversible dementia due to macroprolactinoma. Case report
M H Brisman1, M R Fetell, K D Post
1Department of Neurology, Columbia-Presbyterian Medical Center, New York, New York.
Journal of Neurosurgery
|July 1, 1993
Summary
Subfrontal tumors rarely cause dementia, but treatment can reverse symptoms. A large prolactinoma causing dementia resolved with bromocriptine therapy, restoring the patient's mental status.
Area of Science:
- Neuro-oncology
- Endocrinology
- Geriatric Psychiatry
Background:
- Subfrontal tumors are uncommon causes of dementia.
- Meningiomas are the most frequent subfrontal tumors associated with dementia.
- Surgical resection of these tumors can lead to symptom resolution.
Observation:
- A case report details a patient presenting with dementia.
- The patient had a large prolactinoma, a type of pituitary tumor.
- The dementia was attributed to the mass effect of the prolactinoma.
Findings:
- The prolactinoma significantly shrank following treatment with bromocriptine.
- The patient experienced a complete recovery of cognitive function.
- This indicates a reversible dementia caused by the pituitary tumor.
Implications:
- Dementia associated with pituitary tumors may be reversible with medical therapy.
- Bromocriptine therapy is a viable treatment option for prolactinomas causing neurological deficits.
- Highlights the importance of considering endocrine disorders in dementia workup.