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Meningiomas induced by high-dose cranial irradiation
1Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
Journal of Neurosurgery
|July 1, 1993
Summary
High-dose cranial irradiation can induce meningiomas, particularly in younger patients. The time from radiation therapy to meningioma diagnosis was shorter than previously reported for low-dose exposures.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Meningiomas are typically associated with low-dose cranial irradiation.
- Limited data exists on meningioma induction following high-dose cranial irradiation.
Purpose of the Study:
- To investigate the characteristics and latency of meningiomas developed after high-dose cranial irradiation.
- To explore the correlation between patient age at irradiation and meningioma development.
Main Methods:
- Retrospective analysis of 10 patients with meningiomas and a history of high-dose cranial irradiation.
- Pathological examination of eight meningiomas, including bromodeoxyuridine labeling index.
- Correlation analysis of patient age at irradiation and tumor latency.
Main Results:
- Eight patients were female; three had multiple meningiomas.
- Half of the examined meningiomas were aggressive or atypical.
- Average latency was 24 years, shorter than with low-dose irradiation.
- Younger age at irradiation correlated with shorter tumor latency.
Conclusions:
- High-dose cranial irradiation can induce meningiomas with potentially aggressive features.
- Tumor latency is influenced by radiation dose and patient age at exposure.
- Further research is needed to understand the long-term risks of high-dose cranial irradiation.