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Related Experiment Videos

Growth failure in pediatric inflammatory bowel disease

J Markowitz1, K Grancher, J Rosa

  • 1Department of Pediatrics, North Shore University Hospital, Manhasset, NY 11030.

Journal of Pediatric Gastroenterology and Nutrition
|May 1, 1993
PubMed
Summary

Children with inflammatory bowel disease (IBD) often experience permanent growth impairment, with 19-35% showing reduced adult height. Longer corticosteroid use was linked to impaired growth in these pediatric patients.

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Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Growth and Development

Background:

  • Inflammatory bowel disease (IBD) is a chronic condition affecting children and adolescents.
  • Concerns exist regarding the long-term impact of IBD on linear growth and final adult height.
  • Understanding growth patterns in pediatric IBD is crucial for effective management.

Purpose of the Study:

  • To determine the prevalence of permanent linear growth impairment in young adults with a history of childhood or early adolescent IBD.
  • To identify factors associated with growth deficits in this population.
  • To evaluate the accuracy of different prediction methods for assessing ultimate adult height.

Main Methods:

  • Analysis of medical records from 48 young adults diagnosed with IBD during Tanner stages I-III.

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  • Prediction of adult height using height-for-age percentile, Bailey-Pinneau (BP), and Roche-Wainer-Thissen (RWT) methods.
  • Comparison of predicted adult heights with actual achieved final heights.

    • Main Results:

    • Permanent growth failure was observed in 19-35% of subjects, depending on the assessment method.
    • 31% of subjects exhibited height deficits identified by at least two prediction methods.
    • Longer duration of corticosteroid use was significantly associated with impaired growth (p < 0.05).

    Conclusions:

    • Permanent impairment of linear growth is common in individuals with a history of pediatric or early adolescent IBD.
    • Clinically meaningful deficits in adult height can result from childhood IBD.
    • There is a need for novel therapeutic strategies to mitigate growth problems in pediatric IBD patients.