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Updated: Aug 25, 2026

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Fluid retention and cardiomegaly associated with carbamazepine in an epileptic child

S Atalay1, A Oner, Y K Gürer

  • 1Department of Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Türkiye.

Japanese Heart Journal
|March 1, 1993
PubMed

Insights

Carbamazepine (CBZ) can cause fluid overload and heart enlargement in children, a rare side effect. This case highlights the syndrome of inappropriate antidiuretic hormone secretion (SIADH) linked to CBZ in pediatric patients.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Pharmacology
  • Neurology

Background:

  • Carbamazepine (CBZ) is known to cause antidiuretic effects, a recognized complication in adults.
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to CBZ is rarely reported in children.
  • Fluid overload and cardiomegaly are potential adverse effects of CBZ therapy.

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