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Oxidized low-density lipoprotein in experimental focal glomerulosclerosis
A B Magil1, J J Frohlich, S M Innis
1Department of Medicine, University of British Columbia, Vancouver, Canada.
Kidney International
|June 1, 1993
Summary
Oxidized low-density lipoproteins (Ox-LDL) were found in glomeruli of rats with experimental focal glomerulosclerosis (FGS). This suggests Ox-LDL plays a role in FGS, similar to its role in atherosclerosis.
Area of Science:
- Nephrology
- Cardiovascular Research
- Pathology
Background:
- Oxidized low-density lipoproteins (Ox-LDL) are implicated in atherosclerosis pathogenesis.
- Focal glomerulosclerosis (FGS) shares similarities with atherosclerosis.
Purpose of the Study:
- To investigate the presence and role of Ox-LDL in experimental focal glomerulosclerosis (FGS).
Main Methods:
- FGS was induced in rats using a cholesterol-rich diet and puromycin aminonucleoside.
- Immunohistochemistry was used to detect Ox-LDL and monocytes in glomeruli.
- Lipid analysis of isolated glomeruli was performed.
Main Results:
- Test animals exhibited hypercholesterolemia, proteinuria, and FGS in 20% of glomeruli.
- Ox-LDL was detected intracellularly in glomeruli of test rats.
- Increased intraglomerular monocytes and altered glomerular lipid profiles were observed in test rats.
Conclusions:
- Findings suggest a role for Ox-LDL in the pathogenesis of experimental FGS.
- The results support the hypothesis that FGS is analogous to atherosclerosis.