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Heterogeneity of centronuclear myopathy shown by flow cytometry of nuclear DNA
K Metze1, R Schnabel, W Mellin
1Institute of Neuropathology Bethel, Bielefeld, Germany.
Neuropathology and Applied Neurobiology
|April 1, 1993
Abstract:
Determination of nuclear DNA by flow cytometry of skeletal muscle biopsies of three unrelated male patients with centronuclear (myotubular) myopathy demonstrated, in two patients, a normal pattern and, in one case, a near haploid DNA content in c. 60% of all nuclei, indicating muscle tissue mosaicism.